Livestock Metabolism and Residue Studies

  • Fera is your perfect partner for GLP compliant livestock metabolism and residue studies with radiolabelled and non-radiolabelled chemicals. Investigations into absorption and excretion can also be included in such studies.
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Livestock Metabolism and Residue Studies


Animal Metabolism Studies

Metabolism studies are conducted to determine the nature of residues and the test substance’s metabolic pathways in animals. We work with partners to design and plan every detail of a study to best meet the product development and/or regulatory compliance needs.  Our GLP-compliant studies range from preliminary tests to determining the uptake of 14C radiolabelled agrochemicals and metabolite profiles.  The analytical phase of metabolism studies is performed in our laboratories by expert and experienced staff. Total radioactive residue, extractions, matrix clean up, isolations, and characterisation/radio profiles of the incurred residue are tailored and performed to satisfy routine as well as complex projects with exceptional care and quality. Elucidating the structure of novel metabolites is often technically challenging and requires the attention of experienced metabolic chemists. Our laboratories contain advanced chromatographic and mass spectrometry equipment including NMR, LC-Tof, LC-Qtof and LC-Orbitrap which provide an efficient metabolite profiling and identification service.

Our Services
Sheep
Cows


Working with us:

  • Our studies will determine the nature of your products’ residues and metabolic pathways in animals as well as assess the potential for their accumulation and metabolism in soil residue – providing the reliable data you need to make product development decisions.
  • We can help you at every stage of the process, from requirements assessment and study design to execution and dossier development. We can perform single studies for product registration and complex, customised projects to meet your unique requirements. 
  • We have extensive in vitro and in vivo experience and can accurately isolate, identify and characterise known and unknown metabolites in tissues and excreta.


Services and capabilities

Livestock facilities

Our ability to use commercial farm scale trials, environmental risk assessments and both laboratory and field studies allows us to work with most livestock species. Such livestock include cattle, sheep, goats, pigs, rabbits and poultry.

Radio-analytical capability

We use radio-HPLC, radio-LC-MS/MS, radio-TLC, LSC, bio-imaging and combustion analysis to quantify residues and identify metabolites. 

Sheep
Service Description
ADME Studies ADME studies to determine plasma and tissue kinetics, routes and rates of excretion and provide structural identification of metabolites
Method Development Design of research and development programmes (for the registration of novel veterinary & generics to support desired label claims)
Project Support  Management and coordination of existing development projects or of component parts of sponsors
Efficacy Studies Design and execution of clinical programmes (efficacy and safety studies, discovery and development) to support desired label claims
Clinical Field Trials Clinical field trial network and experience
Exposure Modelling Data gap analysis and development of testing strategies, co-ordination of the assembly and submission of regulatory dossiers and the response to questions to minimise delays and ensure on time product approval. Writing of technical manuals, practitioner information and scientific papers to support successful product commercialisation strategies.
Cows


Veterinary medicine:

  • VICH GL 46 – Metabolism and residue kinetics.
  • VICH GL 47 – Laboratory animal comparative metabolism.
  • VICH GL 48 – Marker residue depletion.

Feed additives

  • EFSA guidance for establishing the safety of additives for the consumer.

Why choose Fera?

  • Capability

    We have the capacity to deliver with 4km of lab benching and 350 scientists analysing over 100,000 samples per year

  • Bespoke Studies

    We can work with you to understand your requirements and design bespoke studies to address these

  • High-tech solutions

    We use a combination of state of the art LC-MS/MS triple quadrupole instruments; radiochemistry and test item application techniques to ensure that experimental studies generate relevant and valid data

  • We have scientific heritage that stretches back over 100 years

    We have the scientific expertise to perform industry leading research

Why choose Fera?
Livestock

UK National Reference Laboratory for Veterinary Medicines 

As the UK National Reference Laboratory for veterinary medicines, and with more than 50 mass spectrometers on site, we offer a comprehensive analytical capability for target-compound analysis.


Find out more


Coming Soon - Plant Metabolism

If you need any further information on our livestock metabolism and residues studies or interested in our new Plant Metabolism service, please get in touch.


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