Metabolism studies are conducted to determine the nature of residues and the test substance’s metabolic pathways in animals. We work with partners to design and plan every detail of a study to best meet the product development and/or regulatory compliance needs. Our GLP-compliant studies range from preliminary tests to determining the uptake of 14C radiolabelled agrochemicals and metabolite profiles. The analytical phase of metabolism studies is performed in our laboratories by expert and experienced staff. Total radioactive residue, extractions, matrix clean up, isolations, and characterisation/radio profiles of the incurred residue are tailored and performed to satisfy routine as well as complex projects with exceptional care and quality. Elucidating the structure of novel metabolites is often technically challenging and requires the attention of experienced metabolic chemists. Our laboratories contain advanced chromatographic and mass spectrometry equipment including NMR, LC-Tof, LC-Qtof and LC-Orbitrap which provide an efficient metabolite profiling and identification service.
Our ability to use commercial farm scale trials, environmental risk assessments and both laboratory and field studies allows us to work with most livestock species. Such livestock include cattle, sheep, goats, pigs, rabbits and poultry.
We use radio-HPLC, radio-LC-MS/MS, radio-TLC, LSC, bio-imaging and combustion analysis to quantify residues and identify metabolites.
|ADME Studies||ADME studies to determine plasma and tissue kinetics, routes and rates of excretion and provide structural identification of metabolites
|Method Development||Design of research and development programmes (for the registration of novel veterinary & generics to support desired label claims)
|Project Support||Management and coordination of existing development projects or of component parts of sponsors
|Efficacy Studies||Design and execution of clinical programmes (efficacy and safety studies, discovery and development) to support desired label claims
|Clinical Field Trials||Clinical field trial network and experience
|Exposure Modelling||Data gap analysis and development of testing strategies, co-ordination of the assembly and submission of regulatory dossiers and the response to questions to minimise delays and ensure on time product approval.
Writing of technical manuals, practitioner information and scientific papers to support successful product commercialisation strategies.
We have the capacity to deliver with 4km of lab benching and 350 scientists analysing over 100,000 samples per year
We can work with you to understand your requirements and design bespoke studies to address these
We use a combination of state of the art LC-MS/MS triple quadrupole instruments; radiochemistry and test item application techniques to ensure that experimental studies generate relevant and valid data
We have the scientific expertise to perform industry leading research
As the UK National Reference Laboratory for veterinary medicines, and with more than 50 mass spectrometers on site, we offer a comprehensive analytical capability for target-compound analysis.
Copyright © 2020 Fera Science Limited (“Fera”). All rights reserved.
Registered Office: 30 Berners Street, London, W1T 3LR. Registered in England & Wales, No 9413107. Fera is a joint venture company of Capita Plc, 30 Berners Street, London, W1T 3LR. Registered in England and Wales No 02081330. VAT Registration ID: GB 618184140
For further information about how Fera uses any personal data collected from you, please see our Privacy Notice at www.fera.co.uk/privacy-policy.